Mapping transgene insertion sites reveals the α-Cre transgene expression in both developing retina and olfactory neurons
The Pax6-α-Cre mouse line used in retinal studies actually contains four transgene insertion within gene clusters of olfactory and vomeronasal receptors, leading to expression in not just retinal, but also olfactory and vomeronasal sensory neurons.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03379-9 |
| _version_ | 1818250475256938496 |
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| author | Yimeng Fan Wenyue Chen Ran Wei Wei Qiang Joel D. Pearson Tao Yu Rod Bremner Danian Chen |
| author_facet | Yimeng Fan Wenyue Chen Ran Wei Wei Qiang Joel D. Pearson Tao Yu Rod Bremner Danian Chen |
| author_sort | Yimeng Fan |
| collection | DOAJ |
| description | The Pax6-α-Cre mouse line used in retinal studies actually contains four transgene insertion within gene clusters of olfactory and vomeronasal receptors, leading to expression in not just retinal, but also olfactory and vomeronasal sensory neurons. |
| first_indexed | 2024-12-12T15:52:59Z |
| format | Article |
| id | doaj.art-f321428e28b24f4799fff4221b78fcda |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-12T15:52:59Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-f321428e28b24f4799fff4221b78fcda2022-12-22T00:19:33ZengNature PortfolioCommunications Biology2399-36422022-05-015111110.1038/s42003-022-03379-9Mapping transgene insertion sites reveals the α-Cre transgene expression in both developing retina and olfactory neuronsYimeng Fan0Wenyue Chen1Ran Wei2Wei Qiang3Joel D. Pearson4Tao Yu5Rod Bremner6Danian Chen7Research Laboratory of Ophthalmology and Vision Sciences, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityResearch Laboratory of Ophthalmology and Vision Sciences, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityResearch Laboratory of Ophthalmology and Vision Sciences, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityResearch Laboratory of Ophthalmology and Vision Sciences, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityLunenfeld-Tanenbaum Research Institute, Sinai Health System, and Departments of Ophthalmology and Visual Science, and Laboratory Medicine and Pathobiology, University of TorontoLunenfeld-Tanenbaum Research Institute, Sinai Health System, and Departments of Ophthalmology and Visual Science, and Laboratory Medicine and Pathobiology, University of TorontoLunenfeld-Tanenbaum Research Institute, Sinai Health System, and Departments of Ophthalmology and Visual Science, and Laboratory Medicine and Pathobiology, University of TorontoResearch Laboratory of Ophthalmology and Vision Sciences, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityThe Pax6-α-Cre mouse line used in retinal studies actually contains four transgene insertion within gene clusters of olfactory and vomeronasal receptors, leading to expression in not just retinal, but also olfactory and vomeronasal sensory neurons.https://doi.org/10.1038/s42003-022-03379-9 |
| spellingShingle | Yimeng Fan Wenyue Chen Ran Wei Wei Qiang Joel D. Pearson Tao Yu Rod Bremner Danian Chen Mapping transgene insertion sites reveals the α-Cre transgene expression in both developing retina and olfactory neurons Communications Biology |
| title | Mapping transgene insertion sites reveals the α-Cre transgene expression in both developing retina and olfactory neurons |
| title_full | Mapping transgene insertion sites reveals the α-Cre transgene expression in both developing retina and olfactory neurons |
| title_fullStr | Mapping transgene insertion sites reveals the α-Cre transgene expression in both developing retina and olfactory neurons |
| title_full_unstemmed | Mapping transgene insertion sites reveals the α-Cre transgene expression in both developing retina and olfactory neurons |
| title_short | Mapping transgene insertion sites reveals the α-Cre transgene expression in both developing retina and olfactory neurons |
| title_sort | mapping transgene insertion sites reveals the α cre transgene expression in both developing retina and olfactory neurons |
| url | https://doi.org/10.1038/s42003-022-03379-9 |
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