A novel regulatory axis of MSI2-AGO2/miR-30a-3p-CGRRF1 drives cancer chemoresistance by upregulating the KRAS/ERK pathway

A novel regulatory axis of MSI2-AGO2/miR-30a-3p-CGRRF1 drives cancer chemoresistance by upregulating the KRAS/ERK pathway

The KRAS/ERK pathway is crucial in cancer progression and chemotherapy resistance, yet its upstream regulatory mechanism remains elusive. We identified MSI2 as a new promoter of chemotherapy resistance in cancers. MSI2 directly binds to a specific class of mature miRNAs by recognizing the 'UAG&...

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Bibliographic Details
Main Authors: Runhui Lu, Yafan Zhang, Ran Chen, Lian Li, Caihu Huang, Zihan Zhou, Yingting Cao, Hongyan Li, Junya Li, Yixin Zhang, Yanli Wang, Jian Huang, Xian Zhao, Jing Feng, Jianxiu Yu, Chunling Du
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Cancer chemoresistance
RNA binding protein MSI2
miRNA
KRAS
CGRRF1
MAPK/ERK
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558624001234

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http://www.sciencedirect.com/science/article/pii/S1476558624001234

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