Mammalian DNA Polymerase Kappa Activity and Specificity

Mammalian DNA Polymerase Kappa Activity and Specificity

DNA polymerase (pol) kappa is a Y-family translesion DNA polymerase conserved throughout all domains of life. Pol kappa is special6 ized for the ability to copy DNA containing minor groove DNA adducts, especially <i>N</i><sup>2</sup>-dG adducts, as well as to extend primer te...

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Bibliographic Details
Main Authors: Hannah R. Stern, Jana Sefcikova, Victoria E. Chaparro, Penny J. Beuning
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
Y-family
DNA replication
DNA damage
translesion DNA synthesis
primer extension
chemotherapy resistance
Online Access:https://www.mdpi.com/1420-3049/24/15/2805

Internet

https://www.mdpi.com/1420-3049/24/15/2805

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