SLC7A11-ROS/αKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression

SLC7A11-ROS/αKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression

The changes of inflammation and metabolism are two features in nonalcoholic steatohepatitis (NASH). However, how they interact to regulate NASH progression remains largely unknown. Our works have demonstrated the importance of solute carrier family 7 member 11 (SLC7A11) in inflammation and metabolis...

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Bibliographic Details
Main Authors: Tingting Lv, Xiude Fan, Chang He, Suwei Zhu, Xiaofeng Xiong, Wei Yan, Mei Liu, Hongwei Xu, Ruihua Shi, Qin He
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Redox Biology
Subjects:
Nonalcoholic steatohepatitis
SLC7A11
AMPK
NLRP3 inflammasome
Mitophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724001356

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http://www.sciencedirect.com/science/article/pii/S2213231724001356

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