Amphipathic dendritic poly-peptides carrier to deliver antisense oligonucleotides against multi-drug resistant bacteria in vitro and in vivo

Amphipathic dendritic poly-peptides carrier to deliver antisense oligonucleotides against multi-drug resistant bacteria in vitro and in vivo

Abstract Background Outbreaks of infection due to multidrug-resistant (MDR) bacteria, especially Gram-negative bacteria, have become a global health issue in both hospitals and communities. Antisense oligonucleotides (ASOs) based therapeutics hold a great promise for treating infections caused by MD...

Full description

Bibliographic Details
Main Authors: Zhou Chen, Yue Hu, Xinggang Mao, Dan Nie, Hui Zhao, Zheng Hou, Mingkai Li, Jingru Meng, Xiaoxing Luo, Xiaoyan Xue
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Nanobiotechnology
Subjects:
Antibacterial strategy
Antisense
Dendritic poly-peptides
Multidrug-resistant bacteria
Nanoparticles
Delivery
Online Access:https://doi.org/10.1186/s12951-022-01384-y

Internet

https://doi.org/10.1186/s12951-022-01384-y

Similar Items