α-Helical Motif as Inhibitors of Toxic Amyloid-β Oligomer Generation via Highly Specific Recognition of Amyloid Surface

α-Helical Motif as Inhibitors of Toxic Amyloid-β Oligomer Generation via Highly Specific Recognition of Amyloid Surface

Summary: Amyloid fibril surfaces can convert soluble proteins into toxic oligomers and are attractive targets for intervention of protein aggregation diseases. Thus far, molecules identified with inhibitory activity are either large proteins or flat cyclic compounds lacking in specificity. The main...

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Bibliographic Details
Main Authors: Yixiang Jiang, Xuehan Jiang, Xiaodong Shi, Fadeng Yang, Yang Cao, Xuan Qin, Zhanfeng Hou, Mingsheng Xie, Na Liu, Qi Fang, Feng Yin, Wei Han, Zigang Li
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219302056

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http://www.sciencedirect.com/science/article/pii/S2589004219302056

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