Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma

Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma

Abstract Diffuse intrinsic pontine glioma (DIPG) is an aggressive incurable brainstem tumor that targets young children. Complete resection is not possible, and chemotherapy and radiotherapy are currently only palliative. This study aimed to identify potential therapeutic agents using a computationa...

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Bibliographic Details
Main Authors: Guisheng Zhao, Patrick Newbury, Yukitomo Ishi, Eugene Chekalin, Billy Zeng, Benjamin S. Glicksberg, Anita Wen, Shreya Paithankar, Takahiro Sasaki, Amreena Suri, Javad Nazarian, Michael E. Pacold, Daniel J. Brat, Theodore Nicolaides, Bin Chen, Rintaro Hashizume
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Acta Neuropathologica Communications
Subjects:
Diffuse intrinsic pontine glioma
Computational approach
Machine learning
Drug repurposing
Mycophenolate mofetil
Online Access:https://doi.org/10.1186/s40478-022-01463-z

Internet

https://doi.org/10.1186/s40478-022-01463-z

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