Vitamin D3 alters macrophage phenotype and endosomal trafficking markers in dairy cattle naturally infected with Mycobacterium avium subsp. paratuberculosis

Vitamin D3 alters macrophage phenotype and endosomal trafficking markers in dairy cattle naturally infected with Mycobacterium avium subsp. paratuberculosis

Macrophages are important host defense cells in ruminant paratuberculosis (Johne’s Disease; JD), a chronic enteritis caused by Mycobacterium avium subsp. paratuberculosis (MAP). Classical macrophage functions of pathogen trafficking, degradation, and antigen presentation are interrupted in mycobacte...

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Bibliographic Details
Main Authors: Taylor L. T. Wherry, Rohana P. Dassanayake, John P. Bannantine, Shankumar Mooyottu, Judith R. Stabel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mycobacterium avium subsp. paratuberculosis
cattle
vitamin D
macrophage
Rab5
Rab7
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1021657/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.1021657/full

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