Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

Mechanical stress is known to fuel several hallmarks of cancer, ranging from genome instability to uncontrolled proliferation or invasion. Cancer cells are constantly challenged by mechanical stresses not only in the primary tumour but also during metastasis. However, this latter has seldom been stu...

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Bibliographic Details
Main Authors: Deborah Fanfone, Zhichong Wu, Jade Mammi, Kevin Berthenet, David Neves, Kathrin Weber, Andrea Halaburkova, François Virard, Félix Bunel, Catherine Jamard, Hector Hernandez-Vargas, Stephen WG Tait, Ana Hennino, Gabriel Ichim
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
mechanobiology
confinement
anoikis
caspases
IAP
metastasis
Online Access:https://elifesciences.org/articles/73150

Internet

https://elifesciences.org/articles/73150

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