Overexpression of microRNA-195-5p reduces cisplatin resistance and angiogenesis in ovarian cancer by inhibiting the PSAT1-dependent GSK3β/β-catenin signaling pathway

Overexpression of microRNA-195-5p reduces cisplatin resistance and angiogenesis in ovarian cancer by inhibiting the PSAT1-dependent GSK3β/β-catenin signaling pathway

Abstract Background Ovarian cancer (OC) is one of the leading causes for cancer-related deaths among women. MicroRNAs (miRs) have been proved to be vital to the development and progression of OC. Hence, the study aims to evaluate the ability of miR-195-5p affecting cisplatin (DDP) resistance and ang...

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Bibliographic Details
Main Authors: Jun Dai, Rujia Wei, Peihai Zhang, Beihua Kong
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Translational Medicine
Subjects:
MicroRNA-195-5p
Phosphoserine aminotransferase 1
Glycogen synthase kinase-3β/β-catenin signaling pathway
Ovarian cancer
Angiogenesis
Cisplatin resistance
Online Access:http://link.springer.com/article/10.1186/s12967-019-1932-1

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http://link.springer.com/article/10.1186/s12967-019-1932-1

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