Pathologic changes in neuronal intranuclear inclusion disease are linked to aberrant FUS interaction under hyperosmotic stress

Pathologic changes in neuronal intranuclear inclusion disease are linked to aberrant FUS interaction under hyperosmotic stress

CGG repeat expansion in NOTCH2NLC is the genetic cause of neuronal intranuclear inclusion disease (NIID). Previous studies indicated that the CGG repeats can be translated into polyglycine protein (N2CpolyG) which was toxic to neurons by forming intranuclear inclusions (IIs). However, little is know...

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Bibliographic Details
Main Authors: Hui Wang, Yilei Zheng, Jiaxi Yu, Lingchao Meng, Wei Zhang, Daojun Hong, Zhaoxia Wang, Yun Yuan, Jianwen Deng
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Neurobiology of Disease
Subjects:
NOTCH2NLC
CGG repeat expansion
polyG
Intranuclear inclusions
Stress granules
FUS
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123004072

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http://www.sciencedirect.com/science/article/pii/S0969996123004072

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