Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling

The progenitor cells of the developing liver can differentiate toward both hepatocyte and biliary cell fates. In addition to the established roles of TGFβ and Notch signaling in this fate specification process, there is increasing evidence that liver progenitors are sensitive to mechanical cues. Her...

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Bibliographic Details
Main Authors: Kerim B Kaylan, Ian C Berg, Matthew J Biehl, Aidan Brougham-Cook, Ishita Jain, Sameed M Jamil, Lauren H Sargeant, Nicholas J Cornell, Lori T Raetzman, Gregory H Underhill
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/38536