Niclosamide as a chemical probe for analyzing SARS-CoV-2 modulation of host cell lipid metabolism

Niclosamide as a chemical probe for analyzing SARS-CoV-2 modulation of host cell lipid metabolism

IntroductionSARS-CoV-2 subverts host cell processes to facilitate rapid replication and dissemination, and this leads to pathological inflammation.MethodsWe used niclosamide (NIC), a poorly soluble anti-helminth drug identified initially for repurposed treatment of COVID-19, which activates the cell...

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Bibliographic Details
Main Authors: Timothy J. Garrett, Heather Coatsworth, Iqbal Mahmud, Timothy Hamerly, Caroline J. Stephenson, Jasmine B. Ayers, Hoda S. Yazd, Megan R. Miller, John A. Lednicky, Rhoel R. Dinglasan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Microbiology
Subjects:
lipidomics
autophagy
lipophagy
COVID-19
RNA sequencing
metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1251065/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2023.1251065/full

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