Common Transcriptomic Effects of Abatacept and Other DMARDs on Rheumatoid Arthritis Synovial Tissue

Common Transcriptomic Effects of Abatacept and Other DMARDs on Rheumatoid Arthritis Synovial Tissue

ObjectivesOur goal was to assess for the histological and transcriptomic effects of abatacept on RA synovia, and to compare them with previously published data from four other DMARDs: tocilizumab, rituximab, methotrexate, and adalimumab.MethodsSynovial tissue was obtained using ultrasound-guided bio...

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Bibliographic Details
Main Authors: Clement Triaille, Patrick Durez, Tatiana Sokolova, Gaëlle Tilman, Laurent Méric de Bellefon, Christine Galant, Pierre Coulie, Bernard R. Lauwerys, Nisha Limaye
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
synovial biopsy
transcriptomic profiling
abatacept
disease modifying anti-rheumatic drug
synovitis
treatment response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.724895/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.724895/full

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