In Vivo Cannabidiol Treatment Improves Endothelium-Dependent Vasorelaxation in Mesenteric Arteries of Zucker Diabetic Fatty Rats

In Vivo Cannabidiol Treatment Improves Endothelium-Dependent Vasorelaxation in Mesenteric Arteries of Zucker Diabetic Fatty Rats

Background and purpose: We have shown that in vitro treatment with cannabidiol (CBD, 2 h) enhances endothelial function in arteries from Zucker diabetic fatty (ZDF) rats, partly due to a cyclooxygenase (COX)-mediated mechanism. The aim of the present study was to determine whether treatment with CBD...

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Bibliographic Details
Main Authors: Amanda J. Wheal, Khalid Jadoon, Michael D. Randall, Saoirse E. O’Sullivan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
cannabinoid
sodium nitroprusside
vasorelaxation
nitric oxide
cyclooxygenase
ZDF rats
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00248/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00248/full

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