p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis

p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis

The tumour suppressor p120-catenin (p120) controls cadherin-based adhesion. Here, the authors demonstrate that p120 regulates cytokinesis through binding to the centralspindlin component MKLP1 and controls RhoA activity. Loss of p120 in cancer induces multinucleation and chromosomal instability, ind...

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Bibliographic Details
Main Authors: Robert A.H. van de Ven, Jolien S. de Groot, Danielle Park, Robert van Domselaar, Danielle de Jong, Karoly Szuhai, Elsken van der Wall, Oscar M. Rueda, H. Raza Ali, Carlos Caldas, Paul J. van Diest, Martin W. Hetzer, Erik Sahai, Patrick W.B. Derksen
Format: Article
Language:English
Published: Nature Portfolio 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13874

Internet

https://doi.org/10.1038/ncomms13874

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