Chromatin remodeling and nucleoskeleton synergistically control osteogenic differentiation in different matrix stiffnesses

Matrix stiffness plays an important role in determining cell differentiation. The expression of cell differentiation-associated genes can be regulated by chromatin remodeling-mediated DNA accessibility. However, the effect of matrix stiffness on DNA accessibility and its significance for cell differ...

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Bibliographic Details
Main Authors: Xinxin Xu, He Zhang, Yuzhou Li, Fengyi Liu, Zheng Jing, Mingxing Ren, Tao Chen, Yiru Fu, Yanqiu Wu, Ping Ji, Sheng Yang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Materials Today Bio
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006423001217