Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia

Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia

Leishmania parasites harbor a unique network of circular DNA known as kinetoplast DNA (kDNA). The role of kDNA in leishmania infections is poorly understood. Herein, we show that kDNA delivery to the cytosol of Leishmania major infected THP-1 macrophages provoked increased parasite loads when compar...

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Bibliographic Details
Main Authors: Ismail Cem Yilmaz, Emre Dunuroglu, Ihsan Cihan Ayanoglu, Emre Mert Ipekoglu, Muzaffer Yildirim, Nogay Girginkardesler, Yusuf Ozbel, Seray Toz, Ahmet Ozbilgin, Gamze Aykut, Ihsan Gursel, Mayda Gursel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
leishmania
kinetoplast DNA (kDNA)
cGAS
STING
TBK1
amlexanox
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1007070/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1007070/full

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