The longitudinal kinetics of AAV5 vector integration profiles and evaluation of clonal expansion in mice

The longitudinal kinetics of AAV5 vector integration profiles and evaluation of clonal expansion in mice

Adeno-associated virus (AAV)-based vectors are used clinically for gene transfer and persist as extrachromosomal episomes. A small fraction of vector genomes integrate into the host genome, but the theoretical risk of tumorigenesis depends on vector regulatory features. A mouse model was used to inv...

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Bibliographic Details
Main Authors: Ashrafali Mohamed Ismail, Evan Witt, Taren Bouwman, Wyatt Clark, Bridget Yates, Matteo Franco, Sylvia Fong
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV5
AAV5-hFVIII-SQ
vector integration
target enrichment sequencing
common integration site
clonal expansion
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124001104

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http://www.sciencedirect.com/science/article/pii/S2329050124001104

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