Pyrrolizidine alkaloids: An update on their metabolism and hepatotoxicity mechanism

Pyrrolizidine alkaloids (PAs) are among the most hepatotoxic natural compounds that are widely distributed throughout the world. Most PAs are metabolically activated to trigger toxicity. Exposure to herbal medicine containing PAs and food supplements contaminated by PAs is considered to be one of th...

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Bibliographic Details
Main Authors: Jie Xu, Weiqian Wang, Xiao Yang, Aizhen Xiong, Li Yang, Zhengtao Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2019-12-01
Series:Liver Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2542568419300480