Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

Abstract Background The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease (AD). ApoE is produced by both astrocytes and microglia in the brain, whereas hepatocytes produce the majority of apoE found in the periphery. Studies using APOE knock-in and tr...

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Bibliographic Details
Main Authors: Tien-Phat V. Huynh, Chao Wang, Ainsley C. Tran, G. Travis Tabor, Thomas E. Mahan, Caroline M. Francis, Mary Beth Finn, Rebecca Spellman, Melissa Manis, Rudolph E. Tanzi, Jason D. Ulrich, David M. Holtzman
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Molecular Neurodegeneration
Subjects:
apoE
Apolipoprotein E
Amyloid
Aβ
apoE particle
Cre-loxP
Online Access:http://link.springer.com/article/10.1186/s13024-019-0337-1

Internet

http://link.springer.com/article/10.1186/s13024-019-0337-1

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