Interference with glycosaminoglycan-chemokine interactions with a probe to alter leukocyte recruitment and inflammation in vivo.

In vivo leukocyte recruitment is not fully understood and may result from interactions of chemokines with glycosaminoglycans/GAGs. We previously showed that chlorite-oxidized oxyamylose/COAM binds the neutrophil chemokine GCP-2/CXCL6. Here, mouse chemokine binding by COAM was studied systematically...

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Bibliographic Details
Main Authors: Sandra Li, Ulrika S Pettersson, Bart Hoorelbeke, Elzbieta Kolaczkowska, Katrien Schelfhout, Erik Martens, Paul Kubes, Jo Van Damme, Mia Phillipson, Ghislain Opdenakker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25093679/pdf/?tool=EBI