Role of the Mycobacterium tuberculosis ESX-4 Secretion System in Heme Iron Utilization and Pore Formation by PPE Proteins

Role of the Mycobacterium tuberculosis ESX-4 Secretion System in Heme Iron Utilization and Pore Formation by PPE Proteins

ABSTRACT Mycobacterium tuberculosis (Mtb) is transmitted through aerosols and primarily colonizes within the lung. The World Health Organization estimates that Mtb kills ~1.4 million people every year. A key aspect that makes Mtb such a successful pathogen is its ability to overcome iron limitation...

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Bibliographic Details
Main Authors: November Sankey, Haley Merrick, Padam Singh, Janet Rogers, Amit Reddi, Steven D. Hartson, Avishek Mitra
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mSphere
Subjects:
Mycobacterium tuberculosis
iron acquisition
heme
type VII secretion
ESX-4
outer membrane
Online Access:https://journals.asm.org/doi/10.1128/msphere.00573-22

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https://journals.asm.org/doi/10.1128/msphere.00573-22

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