Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE.

Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE.

Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine today identified as a key mediator of several chronic inflammatory diseases. TNF-α, initially synthesized as a membrane-anchored precursor (pro-TNF-α), is processed by proteolytic cleavage to generate the secreted mature form. TNF-α...

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Bibliographic Details
Main Authors: Helena Moreira-Tabaka, Jean Peluso, Jean-Luc Vonesch, Didier Hentsch, Pascal Kessler, Jean-Marie Reimund, Serge Dumont, Christian D Muller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3316627?pdf=render

Internet

http://europepmc.org/articles/PMC3316627?pdf=render

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