Present and Future Perspective on PLK1 Inhibition in Cancer Treatment

Present and Future Perspective on PLK1 Inhibition in Cancer Treatment

Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine kinase family. PLK1 has a key role in the progression of mitosis and recent evidence suggest its important involvement in regulating the G2/M checkpoint, in DNA damage and replication stress response, and in cel...

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Bibliographic Details
Main Authors: Michela Chiappa, Serena Petrella, Giovanna Damia, Massimo Broggini, Federica Guffanti, Francesca Ricci
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
cell cycle
G2/M checkpoint
DNA damage response
EMT
PLK1 inhibitors
drug combination
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.903016/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.903016/full

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