Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology

Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology

Abstract Background Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disorder caused by genetic loss of dystrophin protein. Extracellular microRNAs (ex‐miRNAs) are putative, minimally invasive biomarkers of DMD. Specific ex‐miRNAs (e.g. miR‐1, miR‐133a, miR‐206, and miR‐483) are highly up...

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Bibliographic Details
Main Authors: Tirsa L.E. vanWestering, Yulia Lomonosova, Anna M.L. Coenen‐Stass, Corinne A. Betts, Amarjit Bhomra, Margriet Hulsker, Lucy E. Clark, Graham McClorey, Annemieke Aartsma‐Rus, Maaike vanPutten, Matthew J.A. Wood, Thomas C. Roberts
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Duchenne muscular dystrophy
MicroRNA
Biomarkers
Dystrophin
X‐chromosome inactivation
Muscle turnover
Online Access:https://doi.org/10.1002/jcsm.12506

Internet

https://doi.org/10.1002/jcsm.12506

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