Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization

Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization

Abstract Background Neutralizing antibodies (NAbs) protect against HIV-1 acquisition in animal models and show promise in treatment of infection. They act by binding to the viral envelope glycoprotein (Env), thereby blocking its receptor interactions and fusogenic function. The potency of neutraliza...

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Bibliographic Details
Main Authors: Philippe Colin, Rajesh P. Ringe, Anila Yasmeen, Gabriel Ozorowski, Thomas J. Ketas, Wen-Hsin Lee, Andrew B. Ward, John P. Moore, P. J. Klasse
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Retrovirology
Subjects:
HIV-1 neutralization
Broadly active neutralizing antibodies (bNAbs)
Persistent fraction
Efficacy
Antigenic heterogeneity
Stoichiometry
Online Access:https://doi.org/10.1186/s12977-023-00624-9

Internet

https://doi.org/10.1186/s12977-023-00624-9

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