LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C.

LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C.

In budding yeast, the Mitotic Exit Network (MEN) regulates anaphase promoting complex/cyclosome (APC/C) via the Dbf2-Cdc14 signaling cascade. Dbf2 kinase phosphorylates and activates Cdc14 phosphatase, which removes the inhibitory phosphorylation of the APC/C cofactor Cdh1. Although each component o...

Full description

Bibliographic Details
Main Authors: Kenta Masuda, Tatsuyuki Chiyoda, Naoyuki Sugiyama, Aldo Segura-Cabrera, Yasuaki Kabe, Arisa Ueki, Kouji Banno, Makoto Suematsu, Daisuke Aoki, Yasushi Ishihama, Hideyuki Saya, Shinji Kuninaka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4344199?pdf=render

Internet

http://europepmc.org/articles/PMC4344199?pdf=render

Similar Items