Efficient engraftment and viral transduction of human hepatocytes in an FRG rat liver humanization model

Abstract Humanized liver rodent models, in which the host liver parenchyma is repopulated by human hepatocytes, have been increasingly used for drug development and disease research. Unlike the leading humanized liver mouse model in which Fumarylacetoacetate Hydrolase (Fah), Recombination Activating...

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Bibliographic Details
Main Authors: Marisa Carbonaro, Jeffrey Lee, Evangelos Pefanis, Mathieu Desclaux, Kehui Wang, Alexander Pennington, Hui Huang, Alejo Mujica, Jose Rojas, Roxanne Ally, Daniel Kennedy, Michael Brown, Vitaliy Rogulin, Sven Moller-Tank, Leah Sabin, Brian Zambrowicz, Gavin Thurston, Zhe Li
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18119-6