Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition

Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition

An altered liver microenvironment characterized by a dysregulated extracellular matrix (ECM) supports the development and progression of hepatocellular carcinoma (HCC). The development of experimental platforms able to reproduce these physio-pathological conditions is essential in order to identify...

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Bibliographic Details
Main Authors: Giuseppe Mazza, Andrea Telese, Walid Al-Akkad, Luca Frenguelli, Ana Levi, Martina Marrali, Lisa Longato, Kessarin Thanapirom, Maria Giovanna Vilia, Benedetta Lombardi, Claire Crowley, Mark Crawford, Morten A. Karsdal, Diana J. Leeming, Giusi Marrone, Katrin Bottcher, Benjamin Robinson, Armando Del Rio Hernandez, Domenico Tamburrino, Gabriele Spoletini, Massimo Malago, Andrew R. Hall, Jasminka Godovac-Zimmermann, Tu Vinh Luong, Paolo De Coppi, Massimo Pinzani, Krista Rombouts
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cells
Subjects:
hepatocellular carcinoma (hcc)
tumor microenvironment (tme)
3-dimensional (3d) platform
3d ecm scaffolds
decellularized human liver
decellularized extracellular matrix (decm)
proteomics
hepatocellular carcinoma cells
transforming growth factor beta1 (tgf-β1)
tissue engineering
Online Access:https://www.mdpi.com/2073-4409/9/1/83

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https://www.mdpi.com/2073-4409/9/1/83

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