Dual Target Ligands with 4-<i>tert</i>-Butylphenoxy Scaffold as Histamine H<sub>3</sub> Receptor Antagonists and Monoamine Oxidase B Inhibitors

Dual Target Ligands with 4-<i>tert</i>-Butylphenoxy Scaffold as Histamine H<sub>3</sub> Receptor Antagonists and Monoamine Oxidase B Inhibitors

Dual target ligands are a promising concept for the treatment of Parkinson’s disease (PD). A combination of monoamine oxidase B (MAO B) inhibition with histamine H<sub>3</sub> receptor (H<sub>3</sub>R) antagonism could have positive effects on dopamine regulation. Thus, a ser...

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Bibliographic Details
Main Authors: Dorota Łażewska, Agnieszka Olejarz-Maciej, David Reiner, Maria Kaleta, Gniewomir Latacz, Małgorzata Zygmunt, Agata Doroz-Płonka, Tadeusz Karcz, Annika Frank, Holger Stark, Katarzyna Kieć-Kononowicz
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
dual-target ligands
histamine H<sub>3</sub> receptor
monoamine oxidase B
4-<i>tert</i>-butylphenyl derivatives
antagonists
inhibitors
Online Access:https://www.mdpi.com/1422-0067/21/10/3411

Internet

https://www.mdpi.com/1422-0067/21/10/3411

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