Pregnenolone and progesterone production from natural sterols using recombinant strain of Mycolicibacterium smegmatis mc2 155 expressing mammalian steroidogenesis system

Pregnenolone and progesterone production from natural sterols using recombinant strain of Mycolicibacterium smegmatis mc2 155 expressing mammalian steroidogenesis system

Abstract Background Pregnenolone and progesterone are the life-important steroid hormones regulating essential vital functions in mammals, and widely used in different fields of medicine. Microbiological production of these compounds from sterols is based on the use of recombinant strains expressing...

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Bibliographic Details
Main Authors: Mikhail Karpov, Nicolai Strizhov, Ludmila Novikova, Tatyana Lobastova, Sergey Khomutov, Andrei Shutov, Alexey Kazantsev, Marina Donova
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Microbial Cell Factories
Subjects:
Cytochrome P450scc
Progesterone
Pregnenolone
Sterols
3-methoxymethylated steroids
Mycolicibacterium smegmatis mc2 155
Online Access:https://doi.org/10.1186/s12934-024-02385-2

Internet

https://doi.org/10.1186/s12934-024-02385-2

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