Soluble tumor necrosis factor-alpha-induced hyperexcitability contributes to retinal ganglion cell apoptosis by enhancing Nav1.6 in experimental glaucoma

Soluble tumor necrosis factor-alpha-induced hyperexcitability contributes to retinal ganglion cell apoptosis by enhancing Nav1.6 in experimental glaucoma

Abstract Background Neuroinflammation plays an important role in the pathogenesis of glaucoma. Tumor necrosis factor-alpha (TNF-α) is a major pro-inflammatory cytokine released from activated retinal glial cells in glaucoma. Here, we investigated how TNF-α induces retinal ganglion cell (RGC) hyperex...

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Bibliographic Details
Main Authors: Shuo Cheng, Hong-Ning Wang, Lin-Jie Xu, Fang Li, Yanying Miao, Bo Lei, Xinghuai Sun, Zhongfeng Wang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Neuroinflammation
Subjects:
TNF-α
Nav1.6
Hyperexcitability
Neuroinflammation
Retinal ganglion cells
Apoptosis
Online Access:https://doi.org/10.1186/s12974-021-02236-6

Internet

https://doi.org/10.1186/s12974-021-02236-6

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