Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp)

Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp)

BACKGROUND Since the World Health Organization (WHO) declared Coronavirus disease 2019 (COVID-19) to be a pandemic infection, important severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural proteins (nsp) have been analysed as promising targets in virtual screening approaches....

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Bibliographic Details
Main Authors: Felipe Moura A da Silva, Katia Pacheco A da Silva, Luiz Paulo M de Oliveira, Emmanoel V Costa, Hector HF Koolen, Maria Lúcia B Pinheiro, Antonia Queiroz L de Souza, Afonso Duarte L de Souza
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2020-09-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
COVID-19
rutin
nicotiflorin
glucuronides
Dysphania ambrosioides
phytomedicines
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762020000100341&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762020000100341&tlng=en

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