Sex differences in the medial prefrontal cortical glutamate system

Sex differences in the medial prefrontal cortical glutamate system

Highlights Female mice exhibit heightened synaptosomal expression of AMPAR subunits GluA1 and GluA2 in the mPFC compared to males. Females have enhanced glutamatergic transmission in the mPFC compared to males. There are baseline sex differences in the mPFC glutamate system that may underlie sex dif...

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Bibliographic Details
Main Authors: Melissa C. Knouse, Anna G. McGrath, Andre U. Deutschmann, Matthew T. Rich, Lia J. Zallar, Anjali M. Rajadhyaksha, Lisa A. Briand
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Biology of Sex Differences
Subjects:
Medial prefrontal cortex
Sex differences
AMPA receptors
Glutamate
Excitatory transmission
Online Access:https://doi.org/10.1186/s13293-022-00468-6

Internet

https://doi.org/10.1186/s13293-022-00468-6

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