Selenium and zinc alleviate quaternary metal mixture -induced neurotoxicity in rats by inhibiting oxidative damage and modulating the expressions of NF-kB and Nrf2/Hmox-1 pathway

Selenium and zinc alleviate quaternary metal mixture -induced neurotoxicity in rats by inhibiting oxidative damage and modulating the expressions of NF-kB and Nrf2/Hmox-1 pathway

Background: This study evaluated the potential protective effects of Zn and Se in the cerebellum and cerebral cortex, two fundamentally important brain regions, in albino rats that were exposed to heavy metals mixture (Al, Pb, Hg and Mn). Methods: Animals were divided into five groups of seven anima...

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Bibliographic Details
Main Authors: Chinyere Dike, Chinna N. Orish, Anthonet N. Ezejiofor, Ana Cirovic, Aleksandar Cirovic, Bolaji Babatunde, Francis Sikoki, Orish E. Orisakwe
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:IBRO Neuroscience Reports
Subjects:
Cerebellum
Cerebral cortex
Heavy metals mixture
Beneficial effects of Zn and Se
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242123000519

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http://www.sciencedirect.com/science/article/pii/S2667242123000519

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