Dissecting insect cell heterogeneity during influenza VLP production using single-cell transcriptomics

Dissecting insect cell heterogeneity during influenza VLP production using single-cell transcriptomics

The insect cell-baculovirus expression vector system (IC-BEVS) has been widely used to produce recombinant protein at high titers, including complex virus-like particles (VPLs). However, cell-to-cell variability upon infection is yet one of the least understood phenomena in virology, and little is k...

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Bibliographic Details
Main Authors: Marco Silvano, Nikolaus Virgolini, Ricardo Correia, Colin Clarke, Inês A. Isidro, Paula M. Alves, António Roldão
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
IC-BEVS
influenza VLP
single-cell RNA sequencing
cell heterogeneity
pathway analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1143255/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1143255/full

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