MTHFR Gene Polymorphism Association With Psoriatic Arthritis Risk and the Efficacy and Hepatotoxicity of Methotrexate in Psoriasis

MTHFR Gene Polymorphism Association With Psoriatic Arthritis Risk and the Efficacy and Hepatotoxicity of Methotrexate in Psoriasis

AimsTo assess whether MTHFR rs1801131 and rs1801133 SNPs are associated with concomitant psoriatic arthritis (PsA) and investigate the efficacy and hepatotoxicity of MTX in patients with psoriasis in the Han Chinese population.MethodsThis prospective, single-arm, interventional study recruited a tot...

Full description

Bibliographic Details
Main Authors: Jie Zhu, Zhicheng Wang, Lu Tao, Ling Han, Qiong Huang, Xu Fang, Ke Yang, Guiqin Huang, Zhizhong Zheng, Nikhil Yawalkar, Zhenghua Zhang, Kexiang Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Medicine
Subjects:
methylenetetrahydrofolate reductase
psoriasis
psoriatic arthritis
methotrexate
biomarker
pharmacogenetics
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.869912/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.869912/full

Similar Items