Benefits of FAIMS to Improve the Proteome Coverage of Deteriorated and/or Cross-Linked TMT 10-Plex FFPE Tissue and Plasma-Derived Exosomes Samples

Benefits of FAIMS to Improve the Proteome Coverage of Deteriorated and/or Cross-Linked TMT 10-Plex FFPE Tissue and Plasma-Derived Exosomes Samples

The proteome characterization of complex, deteriorated, or cross-linked protein mixtures as paired clinical FFPE or exosome samples isolated from low plasma volumes (250 µL) might be a challenge. In this work, we aimed at investigating the benefits of FAIMS technology coupled to the Orbitrap Explori...

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Bibliographic Details
Main Authors: Ana Montero-Calle, María Garranzo-Asensio, Raquel Rejas-González, Jaime Feliu, Marta Mendiola, Alberto Peláez-García, Rodrigo Barderas
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Proteomes
Subjects:
FAIMS
Orbitrap Exploris 480
FFPE tissue
exosomes
protein coverage
proteomics
Online Access:https://www.mdpi.com/2227-7382/11/4/35

Internet

https://www.mdpi.com/2227-7382/11/4/35

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