Semi-Synthesis of Harringtonolide Derivatives and Their Antiproliferative Activity

Semi-Synthesis of Harringtonolide Derivatives and Their Antiproliferative Activity

Harringtonolide (HO), a natural product isolated from <i>Cephalotaxus harringtonia</i>, exhibits potent antiproliferative activity. However, little information has been reported on the systematic structure−activity relationship (SAR) of HO derivatives. Modifications on tropone, lactone,...

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Bibliographic Details
Main Authors: Xiutao Wu, Lijie Gong, Chen Chen, Ye Tao, Wuxi Zhou, Lingyi Kong, Jianguang Luo
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
harringtonolide
troponoids
structure-activity relationship (SAR)
antiproliferative activity
Online Access:https://www.mdpi.com/1420-3049/26/5/1380

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