Downregulation of chemokine receptor 9 facilitates CD4+CD8αα+ intraepithelial lymphocyte development

Downregulation of chemokine receptor 9 facilitates CD4+CD8αα+ intraepithelial lymphocyte development

Abstract Intestinal intraepithelial lymphocytes (IELs) reside in the gut epithelial layer, where they help in maintaining intestinal homeostasis. Peripheral CD4+ T cells can develop into CD4+CD8αα+ IELs upon arrival at the gut epithelium via the lamina propria (LP). Although this specific differenti...

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Bibliographic Details
Main Authors: Keiko Ono, Tomohisa Sujino, Kentaro Miyamoto, Yosuke Harada, Satoshi Kojo, Yusuke Yoshimatsu, Shun Tanemoto, Yuzo Koda, Jiawen Zheng, Kazutoshi Sayama, Tsuyoshi Koide, Toshiaki Teratani, Yohei Mikami, Kaoru Takabayashi, Nobuhiro Nakamoto, Naoki Hosoe, Mariya London, Haruhiko Ogata, Daniel Mucida, Ichiro Taniuchi, Takanori Kanai
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40950-2

Internet

https://doi.org/10.1038/s41467-023-40950-2

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