A Novel RP-UHPLC-MS/MS Approach for the Determination of Tryptophan Metabolites Derivatized with 2-Bromo-4′-Nitroacetophenone

A Novel RP-UHPLC-MS/MS Approach for the Determination of Tryptophan Metabolites Derivatized with 2-Bromo-4′-Nitroacetophenone

Many biologically active metabolites of the essential amino acid L-tryptophan (Trp) are associated with different neurodegenerative diseases and neurological disorders. Precise and reliable methods for their determination are needed. Variability in their physicochemical properties makes the analytic...

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Bibliographic Details
Main Authors: Timotej Jankech, Ivana Gerhardtova, Petra Majerova, Juraj Piestansky, Lubica Fialova, Josef Jampilek, Andrej Kovac
Format: Article
Language:English
Published: MDPI AG 2024-05-01
Series:Biomedicines
Subjects:
derivatization
liquid chromatography
Alzheimer’s disease
tryptophan metabolites
Online Access:https://www.mdpi.com/2227-9059/12/5/1003

Internet

https://www.mdpi.com/2227-9059/12/5/1003

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