Differential Regulation of 6- and 7-Transmembrane Helix Variants of μ-Opioid Receptor in Response to Morphine Stimulation.

Differential Regulation of 6- and 7-Transmembrane Helix Variants of μ-Opioid Receptor in Response to Morphine Stimulation.

The pharmacological effect of opioids originates, at the cellular level, by their interaction with the μ-opioid receptor (mOR) resulting in the regulation of voltage-gated Ca2+ channels and inwardly rectifying K+ channels that ultimately modulate the synaptic transmission. Recently, an alternative s...

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Bibliographic Details
Main Authors: Marino Convertino, Alexander Samoshkin, Chi T Viet, Josee Gauthier, Steven P Li Fraine, Reza Sharif-Naeini, Brian L Schmidt, William Maixner, Luda Diatchenko, Nikolay V Dokholyan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4640872?pdf=render

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http://europepmc.org/articles/PMC4640872?pdf=render

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