NOTO Transcription Factor Directs Human Induced Pluripotent Stem Cell-Derived Mesendoderm Progenitors to a Notochordal Fate

NOTO Transcription Factor Directs Human Induced Pluripotent Stem Cell-Derived Mesendoderm Progenitors to a Notochordal Fate

The founder cells of the Nucleus pulposus, the centre of the intervertebral disc, originate in the embryonic notochord. After birth, mature notochordal cells (NC) are identified as key regulators of disc homeostasis. Better understanding of their biology has great potential in delaying the onset of...

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Bibliographic Details
Main Authors: Pauline Colombier, Boris Halgand, Claire Chédeville, Caroline Chariau, Valentin François-Campion, Stéphanie Kilens, Nicolas Vedrenne, Johann Clouet, Laurent David, Jérôme Guicheux, Anne Camus
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
human induced pluripotent stem cells
intervertebral disc regeneration
mesendoderm progenitors
notochord
directed differentiation
signalling
stem cell therapy
Online Access:https://www.mdpi.com/2073-4409/9/2/509

Internet

https://www.mdpi.com/2073-4409/9/2/509

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