Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis

Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis

Abstract Background Osteoarthritis (OA) is the common chronic degenerative joint bone disease that is mainly featured by joint stiffness and cartilage degradation. Icariin (ICA), an extract from Epimedium, has been preliminarily proven to show anti-osteoporotic and anti-inflammatory effects in OA. H...

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Bibliographic Details
Main Authors: Yan Zu, Yue Mu, Qiang Li, Shu-Ting Zhang, Hong-Juan Yan
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Icariin
Osteoarthritis
NLRP3 inflammasome
Caspase-1 signaling
Pyroptosis
Online Access:http://link.springer.com/article/10.1186/s13018-019-1307-6

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http://link.springer.com/article/10.1186/s13018-019-1307-6

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