Effect of Cardiotonic Steroid Marinobufagenin on Vascular Remodeling and Cognitive Impairment in Young Dahl-S Rats

Effect of Cardiotonic Steroid Marinobufagenin on Vascular Remodeling and Cognitive Impairment in Young Dahl-S Rats

The hypertensive response in Dahl salt-sensitive (DSS) rats on a high-salt (HS) diet is accompanied by central arterial stiffening (CAS), a risk factor for dementia, and heightened levels of a prohypertensive and profibrotic factor, the endogenous Na/K-ATPase inhibitor marinobufagenin (MBG). We stud...

Full description

Bibliographic Details
Main Authors: Yulia N. Grigorova, Ondrej Juhasz, Jeffrey M. Long, Valentina I. Zernetkina, Mikayla L. Hall, Wen Wei, Christopher H. Morrell, Natalia Petrashevskaya, Audrey Morrow, Katherine H. LaNasa, Alexei Y. Bagrov, Peter R. Rapp, Edward G. Lakatta, Olga V. Fedorova
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
arterial stiffness
behavioral tests
cardiovascular remodeling
Dahl salt-sensitive rats
echocardiography
fibrosis
Online Access:https://www.mdpi.com/1422-0067/23/9/4563

Internet

https://www.mdpi.com/1422-0067/23/9/4563

Similar Items