Synthesis, spectroscopic characterization and antibacterial screening of novel Mannich bases of Ganciclovir
Biologically active Mannich bases with heteroaromatic ring system of substituted guanine derivative (2-amino-9 [{(1,3 di hydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3H-purine-6-one) (ganciclovir), have been synthesized via Mannich reaction. The aminomethylation of ganciclovir with various biologic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535213000452 |
| _version_ | 1818545421669105664 |
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| author | Sheela Joshi Purti Bilgaiyan Anju Pathak |
| author_facet | Sheela Joshi Purti Bilgaiyan Anju Pathak |
| author_sort | Sheela Joshi |
| collection | DOAJ |
| description | Biologically active Mannich bases with heteroaromatic ring system of substituted guanine derivative (2-amino-9 [{(1,3 di hydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3H-purine-6-one) (ganciclovir), have been synthesized via Mannich reaction. The aminomethylation of ganciclovir with various biologically potent sulphonamides was carried out and then characterized by elemental analysis and spectral studies – UV, IR, 1H NMR, powder X-ray diffraction and Scanning Electron Microscopy. The compounds were screened for their antibacterial activity against various pathogenic bacteria at varying concentrations. The antibacterial activity of derived Mannich bases was compared with parent sulphonamides. The toxicity of synthesized Mannich bases was ascertained by LD50 test. |
| first_indexed | 2024-12-12T07:40:02Z |
| format | Article |
| id | doaj.art-f392a608452a48f78b59d5707066954c |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-12T07:40:02Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-f392a608452a48f78b59d5707066954c2022-12-22T00:32:49ZengElsevierArabian Journal of Chemistry1878-53522017-02-0110S1S1180S118710.1016/j.arabjc.2013.02.013Synthesis, spectroscopic characterization and antibacterial screening of novel Mannich bases of GanciclovirSheela JoshiPurti BilgaiyanAnju PathakBiologically active Mannich bases with heteroaromatic ring system of substituted guanine derivative (2-amino-9 [{(1,3 di hydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3H-purine-6-one) (ganciclovir), have been synthesized via Mannich reaction. The aminomethylation of ganciclovir with various biologically potent sulphonamides was carried out and then characterized by elemental analysis and spectral studies – UV, IR, 1H NMR, powder X-ray diffraction and Scanning Electron Microscopy. The compounds were screened for their antibacterial activity against various pathogenic bacteria at varying concentrations. The antibacterial activity of derived Mannich bases was compared with parent sulphonamides. The toxicity of synthesized Mannich bases was ascertained by LD50 test.http://www.sciencedirect.com/science/article/pii/S18785352130004522-Amino-9[{(1,3 di hydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3H-purine-6-one (ganciclovir)SulphonamidesMannich reactionMannich basesAntibacterial activity |
| spellingShingle | Sheela Joshi Purti Bilgaiyan Anju Pathak Synthesis, spectroscopic characterization and antibacterial screening of novel Mannich bases of Ganciclovir Arabian Journal of Chemistry 2-Amino-9[{(1,3 di hydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3H-purine-6-one (ganciclovir) Sulphonamides Mannich reaction Mannich bases Antibacterial activity |
| title | Synthesis, spectroscopic characterization and antibacterial screening of novel Mannich bases of Ganciclovir |
| title_full | Synthesis, spectroscopic characterization and antibacterial screening of novel Mannich bases of Ganciclovir |
| title_fullStr | Synthesis, spectroscopic characterization and antibacterial screening of novel Mannich bases of Ganciclovir |
| title_full_unstemmed | Synthesis, spectroscopic characterization and antibacterial screening of novel Mannich bases of Ganciclovir |
| title_short | Synthesis, spectroscopic characterization and antibacterial screening of novel Mannich bases of Ganciclovir |
| title_sort | synthesis spectroscopic characterization and antibacterial screening of novel mannich bases of ganciclovir |
| topic | 2-Amino-9[{(1,3 di hydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3H-purine-6-one (ganciclovir) Sulphonamides Mannich reaction Mannich bases Antibacterial activity |
| url | http://www.sciencedirect.com/science/article/pii/S1878535213000452 |
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