Microbial metabolites indole derivatives sensitize mice to D-GalN/LPS induced-acute liver failure via the Tlr2/NF-κB pathway

Microbial metabolites indole derivatives sensitize mice to D-GalN/LPS induced-acute liver failure via the Tlr2/NF-κB pathway

IntroductionAcute liver failure (ALF) is a clinical condition with many causes, fast progression, and a poor prognosis. Previous research has indicated that microbial factors have a role in ALF, but a clear picture has yet to emerge.MethodsTo investigate the specific involvement of microbial metabol...

Full description

Bibliographic Details
Main Authors: Ziyuan Zhou, Baohong Wang, Xiaxia Pan, Jiawen Lv, Zhuoqi Lou, Yuqiu Han, Yuanyuan Yao, Jun Chen, Qiangqiang Wang, Lanjuan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Microbiology
Subjects:
microbial metabolites
indole derivatives
acute liver failure
toll-like receptor 2
NF-κB
gut microbiota
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1103998/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.1103998/full

Similar Items