Inhibition of WEE1 Suppresses the Tumor Growth in Laryngeal Squamous Cell Carcinoma

Inhibition of WEE1 Suppresses the Tumor Growth in Laryngeal Squamous Cell Carcinoma

WEE1 is a tyrosine kinase that regulates G2/M cell cycle checkpoint and frequently overexpressed in various tumors. However, the expression and clinical significance of WEE1 in human laryngeal squamous cell carcinoma (LSCC) are still unknown. In this study, we found that WEE1 was highly expressed in...

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Bibliographic Details
Main Authors: Meng-Ling Yuan, Pei Li, Zi-Hao Xing, Jin-Ming Di, Hui Liu, An-Kui Yang, Xi-Jun Lin, Qi-Wei Jiang, Yang Yang, Jia-Rong Huang, Kun Wang, Meng-Ning Wei, Yao Li, Jin Ye, Zhi Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
laryngeal squamous cell carcinoma
WEE1
MK-1775
cell cycle
apoptosis
reactive oxygen species
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01041/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01041/full

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