Rationally designed Campylobacter jejuni Cas9 enables efficient gene activation and base editing

Rationally designed Campylobacter jejuni Cas9 enables efficient gene activation and base editing

Compact and adaptable CRISPR-Cas systems enable genome engineering applications in various contexts via high-efficiency delivery. The adeno-associated virus (AAV) is a widely used delivery system. One of the most compact type II-C Cas9 orthologs—CjCas9, derived from Campylobacter jejuni, is particul...

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Bibliographic Details
Main Authors: Yuxi Chen, Rui Kang, Yuanling Jiang, Qi Zheng, Yue Yang, Jiaqi Liu, Guanglan Wu, Weijun Zhao, Zhan Li, Chengxiang Peng, Pengfei Zhang, Fei Peng, Qianyi Liu, Sihui Hu, Xiao Luo, Guifang Wu, Kaixin Cui, Junjiu Huang, Yongming Wang, Zhou Songyang, Puping Liang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: RNA/DNA Editing
CjCas9
AAV
base editors
retina
mice
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253124002531

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http://www.sciencedirect.com/science/article/pii/S2162253124002531

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